Riordan Clinic Research Institute February 2013 The Riordan IVC Protocol for Adjunctive Cancer Care Intravenous Ascorbate as a Chemotherapeutic and Biological Response Modifying Agent 18 CONCLUSIONS Vitamin C can be safely administered by intravenous infusion at maximum doses of one-hundred grams or less, provided the precautions outlined in this report are taken. At these doses, peak plasma ascorbate concentrations can exceed 20 mM. There are several potential benefits to giving IVC to cancer patients that make it an ideal adjunctive care choice: • Cancer patients are often depleted of vitamin C, and IVC provides an efficient means of restoring tissue stores. • IVC has been shown to improve quality of life in cancer patients by a variety of metrics. • IVC reduces inflammation (as measured by c-reactive protein levels) and reduces the production of pro-inflammatory cytokines. • At high concentrations, ascorbate is preferentially toxic to tumor cells and is an angiogenesis inhibitor. 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